Folklore Clinical Variant Interpretation MCP MCP Server
Variant interpretation, ClinGen gene-disease evidence and biomedical literature for AI agents.
About
Folklore MCP 1.5.0 is Helena Bioinformatics’ public, read-only bioinformatics MCP for genomic variant interpretation, ClinGen gene-disease evidence and literature. Seven tools: search_variant_evidence, search_variant_literature, get_publication_details, search_literature_corpus, get_gene_disease_associations, search_disease_genes, and the optional support_helena helper. Gene symbols/HGNC IDs and disease names/MONDO IDs retrieve source assertions with inheritance, classifications and provenance. Supported GRCh38 germline nuclear SNVs and simple indels remain available for variant evidence queries. Streamable HTTP endpoint: https://api.helena.bio/folklore/v1/mcp. No account or API key. No patient data, VCF uploads, raw DNA ingestion or batch analyses. Scientific results require qualified professional review and are not diagnoses or treatment recommendations.
Security Report
This MCP server is well-structured with strong security fundamentals. It is read-only, stateless, and requires no authentication for public variant data access. Network calls are appropriately scoped to a single trusted endpoint (api.helena.bio), and credential handling follows secure patterns with environment variables. Minor code quality observations around error handling breadth and logging practices do not materially impact security posture.
4 files analyzed · 3 issues found
Security scores are indicators to help you make informed decisions, not guarantees. Always review permissions before connecting any MCP server.
Permissions Required
This plugin requests these system permissions. Most are normal for its category.
How to Install & Connect
Available as Local & Remote
This plugin can run on your machine or connect to a hosted endpoint. during install.
Getting Started
Once installed, try these example prompts and explore these capabilities:
- 1"Find evidence for a supported GRCh38 germline variant"
- 2"Search literature associated with this variant"
- 3Tool: search_variant_evidence returns bounded public evidence
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Version History
Synchronize with Folklore MCP 1.5.0: add ClinGen gene-disease discovery tools and correct seven-tool inventory.
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