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Human Phenotype Ontology — clinical phenotype terms + gene/disease annotations
About
Human Phenotype Ontology — clinical phenotype terms + gene/disease annotations
Remote endpoints: streamable-http: https://gateway.pipeworx.io/hpo-api/mcp
Security Report
Valid MCP server (1 strong, 0 medium validity signals). No known CVEs in dependencies. Imported from the Official MCP Registry. Trust signals: trusted author (443/444 approved). 1 finding(s) downgraded by scanner intelligence.
21 tools verified · Open access · 1 issue found
Security scores are indicators to help you make informed decisions, not guarantees. Always review permissions before connecting any MCP server.
Permissions Required
This plugin requests these system permissions. Most are normal for its category.
How to Connect
Remote Plugin
No local installation needed. Your AI client connects to the remote endpoint directly.
Add this to your MCP configuration to connect:
{
"mcpServers": {
"io-github-pipeworx-io-hpo-api": {
"url": "https://gateway.pipeworx.io/hpo-api/mcp"
}
}
}Documentation
View on GitHubFrom the project's GitHub README.
@pipeworx/hpo-api
Human Phenotype Ontology (HPO) MCP — clinical phenotype terms + gene/disease annotations. Keyless.
Part of Pipeworx — an MCP gateway connecting AI agents to 1394+ live data sources.
Tools
term(id)— HPO term by HP id (e.g.HP:0001250)search(query, limit?, page?)— text search across HPO termsterm_children(id)— direct children of a termterm_parents(id)— direct parents of a termterm_descendants(id)— full descendant subtree (paginated)gene_diseases(id)— diseases associated with a gene id (NCBIGene)disease_phenotypes(id)— HPO terms annotated to a disease (OMIM/ORPHA/MONDO id)
Data source
https://ontology.jax.org/api/hp/ (newer HPO REST) with fallback to https://hpo.jax.org/api/hpo/.
Quick Start
Add to your MCP client (Claude Desktop, Cursor, Windsurf, etc.):
{
"mcpServers": {
"hpo-api": {
"url": "https://gateway.pipeworx.io/hpo-api/mcp"
}
}
}
Or connect to the full Pipeworx gateway for access to all 1394+ data sources:
{
"mcpServers": {
"pipeworx": {
"url": "https://gateway.pipeworx.io/mcp"
}
}
}
Using with ask_pipeworx
Instead of calling tools directly, you can ask questions in plain English:
ask_pipeworx({ question: "your question about Hpo Api data" })
The gateway picks the right tool and fills the arguments automatically.
More
License
MIT
Reviews
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