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Pubchem MCP Server

Developer ToolsLow Risk10.0MCP RegistryRemote
Free

Server data from the Official MCP Registry

PubChem MCP — NIH chemistry compound database (no auth)

About

PubChem MCP — NIH chemistry compound database (no auth)

Remote endpoints: streamable-http: https://gateway.pipeworx.io/pubchem/mcp

Security Report

10.0
Low Risk10.0Low Risk

Valid MCP server (1 strong, 0 medium validity signals). No known CVEs in dependencies. Imported from the Official MCP Registry. Trust signals: trusted author (279/279 approved). 1 finding(s) downgraded by scanner intelligence.

15 tools verified · Open access · 1 issue found

Security scores are indicators to help you make informed decisions, not guarantees. Always review permissions before connecting any MCP server.

Permissions Required

This plugin requests these system permissions. Most are normal for its category.

HTTP Network Access

Connects to external APIs or services over the internet.

How to Connect

Remote Plugin

No local installation needed. Your AI client connects to the remote endpoint directly.

Add this to your MCP configuration to connect:

{
  "mcpServers": {
    "io-github-pipeworx-io-pubchem": {
      "url": "https://gateway.pipeworx.io/pubchem/mcp"
    }
  }
}

Documentation

View on GitHub

From the project's GitHub README.

@pipeworx/pubchem

PubChem MCP — NIH chemistry compound database, no auth.

Part of Pipeworx — an MCP gateway connecting AI agents to 1394+ live data sources.

Tools

  • search_by_name(name, max_results?) — name → CIDs.
  • get_compound(cid) — formula, MW, SMILES, InChI, properties.
  • get_synonyms(cid, max_results?) — all known names.
  • get_classification(cid) — pharmacology classification tree.

Data source

https://pubchem.ncbi.nlm.nih.gov/rest/pug (PUG-REST + PUG-VIEW). No key. Be reasonable on RPS (5/sec recommended).

Quick Start

Add to your MCP client (Claude Desktop, Cursor, Windsurf, etc.):

{
  "mcpServers": {
    "pubchem": {
      "url": "https://gateway.pipeworx.io/pubchem/mcp"
    }
  }
}

Or connect to the full Pipeworx gateway for access to all 1394+ data sources:

{
  "mcpServers": {
    "pipeworx": {
      "url": "https://gateway.pipeworx.io/mcp"
    }
  }
}

Using with ask_pipeworx

Instead of calling tools directly, you can ask questions in plain English:

ask_pipeworx({ question: "your question about Pubchem data" })

The gateway picks the right tool and fills the arguments automatically.

More

License

MIT

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Pubchem MCP Server - PubChem MCP — NIH chemistry compound database (no auth) | MCP Marketplace