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Pre-clinical drug-target intelligence: 60 curated targets, 1,969 counted partner genes, 11 tools
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Pre-clinical drug-target intelligence: 60 curated targets, 1,969 counted partner genes, 11 tools
Security Report
Valid MCP server (1 strong, 3 medium validity signals). No known CVEs in dependencies. Package registry verified. Imported from the Official MCP Registry.
3 files analyzed · 1 issue found
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Permissions Required
This plugin requests these system permissions. Most are normal for its category.
What You'll Need
Set these up before or after installing:
Environment variable: DATABASE_URL
Environment variable: MOSAIC_API_KEY
Environment variable: MOSAIC_TIER
How to Install
Add this to your MCP configuration file:
{
"mcpServers": {
"io-github-sourabhnk-mosaic-mcp": {
"env": {
"MOSAIC_TIER": "your-mosaic-tier-here",
"DATABASE_URL": "your-database-url-here",
"MOSAIC_API_KEY": "your-mosaic-api-key-here"
},
"args": [
"mosaic-mcp"
],
"command": "uvx"
}
}
}Documentation
View on GitHubFrom the project's GitHub README.
mosaic-mcp
Pre-clinical drug-target intelligence as an MCP server: target profiles, compounds, literature, structure, clinical pipeline, validation precedent and whitespace analysis — 11 tools, 5 free and 6 Pro. Every count carries a coverage state, so "we did not look" never renders as zero.
Which one do you want?
This package is bring-your-own-database. It is the MCP tool layer only — it ships the queries, not the data. You point it at a PostgreSQL instance you control, with the Mosaic schema, and it serves the tools over it. There is no public read-only credential for Mosaic's knowledge graph.
If you want Mosaic's curated knowledge graph — 60 oncology targets, ~128K compounds linked to them, 57,896 papers and 9,062 clinical trials (counted 2026-10-07), refreshed monthly — use the hosted server. It needs no database and no local install:
- Claude.ai connector (OAuth, Streamable HTTP):
https://mcp.getmosaic.dev/mcp - Remote MCP with an API key (SSE):
https://mcp.getmosaic.dev/sse - Sign in, API keys and on-demand dossiers for any human gene: https://getmosaic.dev
Quick start (self-hosted)
pip install mosaic-mcp
With Claude Desktop
Add to your claude_desktop_config.json:
{
"mcpServers": {
"mosaic": {
"command": "mosaic-mcp",
"env": {
"DATABASE_URL": "postgresql://USER:PASSWORD@YOUR-HOST:5432/mosaic_db?sslmode=require"
}
}
}
}
With Claude Code
claude mcp add mosaic -- mosaic-mcp
Standalone
export DATABASE_URL="postgresql://..." # your own Postgres
mosaic-mcp # stdio transport
uvx mosaic-mcp and python -m mosaic_mcp.server work too. This package is
stdio-only: --transport sse exits with NotImplementedError, because
remote transport is the hosted server above.
Tools
Free (5)
| Tool | What it returns |
|---|---|
mosaic_get_target_profile | The target dossier: biology, approved and clinical drugs, disease associations ranked by Open Targets, validation evidence, organisations, scores — each axis with its coverage state |
mosaic_get_target_compounds | Compounds with measured activity on the target; sort by potency (default) or by max clinical phase |
mosaic_get_target_papers | Papers about the target, matched by NCBI Gene ID (PubTator3) where your database has the annotations, up to the declared corpus cutoff |
mosaic_get_target_structure | AlphaFold structural snapshot and pockets, with a caution when a pocket is lined by low-confidence residues |
mosaic_get_coverage_grid | A coverage grid for any human gene symbol: identity (HGNC) and structure (AlphaFold DB) resolve live; the other axes are marked queued |
Free calls return up to 10 compounds or papers; Pro up to 50.
Pro (6)
| Tool | What it returns |
|---|---|
mosaic_clinical_pipeline | Clinical trials for compounds acting on the target (a ChEMBL mechanism link or pChEMBL ≥ 6) |
mosaic_target_validation | Assay precedent: what has been tried, in what model system |
mosaic_pathway_context | The pathways the target sits in |
mosaic_target_network | The target's 1-hop neighbourhood: compounds, diseases, pathways, organisations, interacting proteins |
mosaic_synthetic_lethal_whitespace | Partners functionally coupled to the target with little drug activity — assessed candidates and unassessed partners kept apart |
mosaic_resistance_bypass_map | Candidate resistance-bypass and escape targets |
mosaic_request_dossier and mosaic_get_dossier (on-demand dossiers) run only
on the hosted server; they need its fetch and synthesis pipeline.
Configuration
| Variable | Required | Description |
|---|---|---|
DATABASE_URL | Yes | PostgreSQL connection string for your own instance; the path must name the database that holds the Mosaic schema. |
MOSAIC_TIER | No | pro (or enterprise) enables the Pro tools in a self-hosted install. |
MOSAIC_API_KEY | No | In stdio mode any value is treated as Pro; it is not checked locally. Keys are validated by the hosted server. |
Changelog
Full history in CHANGELOG.md. Latest: 2.1.1 — the
mosaic-mcp command starts again (it had failed with ImportError since
1.7.0). 2.1.0 capped mcp below 2, without which a fresh install died on
import, and carried the fixes from a live audit of the hosted server.
License
Apache 2.0 for the MCP server tools. The hosted knowledge graph data requires a subscription for Pro-tier access.
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